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A study of factors which affect the resistance of alveolar macrophages to vaccinia virus.

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dc.contributor.author Shidani, Babak.
dc.date.accessioned 2012-12-11T15:46:30Z
dc.date.available 2012-12-11T15:46:30Z
dc.date.created 1980 en_US
dc.date.issued 2012-12-11
dc.identifier.uri http://hdl.handle.net/123456789/2262
dc.description viii, 74 leaves en_US
dc.description.abstract In vitro systems of pulmonary-alveolar macrophages from normal and vaccinia-immunized rabbits and their counterparts from rabbits stimulated by complete Freund's adjuvant we~ tested for their resistance to the IHD strain of vaccinia virus. It was found that alveolar macrophages could not be induced, either by vaccination or stimulation of the donor animals, to suppress the multiplication of the virus. This finding sets the alveolar macrophages apart from the peritoneal macrophages which do develop the ability to inhibit vaccinia virus when their donors are similarly treated. However, the alveolar macrophages harvested from adjuvant-stimulated animals resisted viral injury even though viral replication was taking place. This suggests that an enhanced physiological state of the alveolar macrophages is important in protecting the cells from vaccinia cytopathology. Because peritoneal macrophages develop resistance, co-incubation of the peritoneal macrophages and alveolar macrophages was done to test the possibility that interaction between two cell types could protect the entire population. This did not occur. In fact, the virus was not inhibited in the mixed macrophage culture. It was concluded that the protective mechanism of the host against a respiratory-originated viral infection is a combination of humoral and cellular immunity and the exact role of the alveolar macrophages in pox viral infection remains to be defined. en_US
dc.language.iso en_US en_US
dc.subject Macrophages-Research. en_US
dc.subject Vaccinia-Research. en_US
dc.title A study of factors which affect the resistance of alveolar macrophages to vaccinia virus. en_US
dc.type Thesis en_US
dc.college las en_US
dc.advisor Helen McElree en_US
dc.department biological sciences en_US

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