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The effects of post-training naloxone administration upon shuttle avoidance performance in the rat.

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dc.contributor.author Syler, John Colladay.
dc.date.accessioned 2012-07-11T15:07:10Z
dc.date.available 2012-07-11T15:07:10Z
dc.date.created 1991 en_US
dc.date.issued 2012-07-11
dc.identifier.uri http://hdl.handle.net/123456789/1852
dc.description 36 leaves en_US
dc.description.abstract Endogenous opioid sUbstances have been demonstrated to have a profound affect on memory and learning alike. In the present study, naloxone hydrochloride was administered to rats intraperitoneally in one of two doses. The sUbjects received post-training doses of either 2.5 mg/kg or 10.0 mg/kg of naloxone and were tested for avoidance response retention in a shuttle paradigm. All animals receiving naloxone were compared to saline controls. The animals were tested for retention 24 hours following training as well as at one week and two weeks respectively. Results indicated that all animals remembered at the 24 hour retention trial. The groups did however differ from each other at one week post-training. Only the low dosage naloxone (2.5 mg/kg) group differed significantly from the other two groups. The low dosage naloxone group had significantly faster approach latencies than either the high dosage naloxone group or the saline group. The results are discussed in terms of behavioral evidence supporting the theory of multiple opiate receptors and in terms of long-term memory consolidation processes. en_US
dc.language.iso en_US en_US
dc.subject Rats. en_US
dc.subject Naloxone. en_US
dc.subject Narcotic antagonists. en_US
dc.title The effects of post-training naloxone administration upon shuttle avoidance performance in the rat. en_US
dc.type Thesis en_US
dc.college the teachers college en_US
dc.advisor Stephen F. Davis en_US
dc.department psychology en_US

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