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Preparation of ¹³C and ¹⁵N modified derivatives of Adenosine and 2ʹ-Deoxyadenosine.

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dc.contributor.author Rana, Geeta.
dc.date.accessioned 2012-06-05T13:43:54Z
dc.date.available 2012-06-05T13:43:54Z
dc.date.created 1999 en_US
dc.date.issued 2012-06-05
dc.identifier.uri http://hdl.handle.net/123456789/1197
dc.description iv, 42 leaves en_US
dc.description.abstract This project deals with synthesis ofmodified nucle ides and their incorporation into 10-base sequence DNA and RNA strands (oligomers). These DNA and RNA fragments possess the proper polarity to easily enter cells through the cell membranes. Enzymes within the cell cleave these molecules, releasing the modified nucleosides. In the present investigation, BC And l~ modified derivatives of adenosine and zt-deoxyadenosine were prepared. These derivatives are prepared to see the bond weakening between base pairs, adenine and 5-ftuoro-zt-deoxyuridine , which are incorporated into two respective strands of DNAorRNA. This would inhibit DNA replication resulting in the death of cancer cells. The studies are being conducted in Eppley Cancer Institute in Omaha, Nebraska to see their effect against various cancer cells and to study base pairing by Nuclear Magnetic Resonance (NMR) spectroscopy. The results of the present research showed the successful formation of unlabeled adenosine by a new synthetic methodology, which will be used to prepare labeled adenosine and BC enrichment at C8 of zt deoxyadenosine. en_US
dc.language.iso en_US en_US
dc.subject DNA. en_US
dc.subject Cancer-Research. en_US
dc.title Preparation of ¹³C and ¹⁵N modified derivatives of Adenosine and 2ʹ-Deoxyadenosine. en_US
dc.type Thesis en_US
dc.college las en_US
dc.advisor Eric Trump en_US
dc.department physical sciences en_US

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